"CIPROFLOXACIN": composition
The broad-spectrum drug is an effective antimicrobial drug belonging to the group of fluoroquinolones.
In tablet form it can have different shades, patterns and coatings. External parameters depend on the manufacturer and dosage of the active substance. In addition, it can be produced in the form of a solution, dry concentrate and drops.
Two types of drops based on this drug are available:
Ophthalmic at a concentration of 0.3% is a transparent yellowish liquid packaged in bottles or polyethylene droppers with a volume of 1 ml, 1.5 ml, 2 ml, 5 ml or 10 ml. Each individual cardboard package contains 1 bottle, 1 or 5 dropper tubes.
Eye and ear drops at a concentration of 0.3% are also a yellowish transparent liquid with a packaging similar to the eye solution.
The medicinal solution contains the active substance ciprofloxacin, presented in the form of hydrochloride monohydrate in a dosage of 3 mg (0.3% of the total volume).
Additional components include:
- mannitol;
- edetate disodium;
- sodium acetate;
- benzalkonium chloride;
- acetic acid solution;
- aqueous injection solution.
special instructions
Wearing contact lenses is not recommended while using the medicine.
The drug is not intended for intraocular injection.
During pregnancy and lactation
The use of the medicine during pregnancy and breastfeeding is permitted under the supervision of a physician.
In childhood
The drug is prescribed to children over 1 year of age under medical supervision. The drug is not used in the treatment of newborns.
For impaired renal function
According to the official instructions for the drug, kidney pathology is not a contraindication for the use of the drug in the form of drops.
Effect on concentration
The drops do not have a direct effect on concentration. But during treatment, side effects such as dizziness and loss of consciousness are possible. When using drops, use caution while driving.
How does it affect the body? (Pharmacodynamics)
Ciprofloxacin is one of the fastest-acting and effective antimicrobial agents. The principle of its effect on the body is to inhibit bacterial DNA gyrase, prevent the growth and reproduction of bacteria and their complete destruction,
The medicine affects both gram-negative and gram-positive microorganisms. For the human body as a whole, the drug is not toxic, does not provoke the development of resistance to other antibiotics, and helps to cope with bacteria that are resistant to drugs of the tetracycline and penicillin groups.
Indications for use:
As a local antibiotic, the medicine is used in ophthalmology in the treatment of diseases such as:
- Blepharitis . A general name for a fairly large group of eye diseases, the main symptom of which is chronic inflammation of the edges of the eyelid.
- Subacute and acute conjunctivitis . The combined name for eye diseases in which inflammatory processes occur on the outer mucous membrane of the eyeball and on the inner surface of the eyelid.
- Blepharoconjunctivitis . A disease characterized by a rapidly developing inflammatory process along the edges of the eyelid and damage to the palpebral and orbital conjunctiva.
- Keratitis . A disease in which the cornea of the eye becomes inflamed, becomes cloudy, and becomes covered with ulcers. The patient experiences noticeable pain. Keratitis can develop either as a result of injury or infection.
- Keratoconjunctivitis . An inflammatory process that involves both the cornea and the area of the palpebral and orbital conjunctiva.
- Meibomite . In common parlance - barley. An inflammatory process affecting the meibomian glands. Symptoms: pain, hyperemia, swelling and purulent infiltrate in the affected area.
- Chronic dacryocystitis . Inflammation of the lacrimal sac, which can be caused by complete or partial stenosis of the nasolacrimal duct.
- Bacterial corneal ulcer . An ulcerative defect of the cornea of the eye caused by a bacterial infection. Accompanied by severe pain. Edema. Decreased vision and clouding of the corneal layer.
- Bacterial damage to the eyes after injury, removal of a foreign body . An inflammatory process that develops as a result of mechanical damage to the eye area and bacterial infection.
Ciprofloxacin is also used for preoperative prevention of bacterial infections. However, this powerful drug has a number of strict contraindications. These include the following diseases and conditions:
- ophthalmomycosis and viral eye infection;
- state of pregnancy and breastfeeding;
- infancy (up to 1 year);
- allergic reaction to the components of the drug.
Possible adverse reactions
The use of the drug does not pose a danger to the patient, since even the drug in one bottle cannot cause intoxication of the body. Side effects are usually mild. These include:
- allergic reaction, mainly skin;
- feeling of nausea;
- swelling of the eyelids;
- increased lacrimation;
- photophobia;
- the appearance of white crystalline formations.
Immediately after instillation, blurred vision, redness of the conjunctiva and burning are usually noted.
If adverse reactions persist for a long time and cause significant discomfort, you should consult a specialist as soon as possible.
Ciprofloxacin eye drops should be kept out of the reach of children.
The causes of central serous chorioretinopathy are described here.
Temporary photophobia is a common side effect of drug treatment
An effective mydriatic remedy is Cyclomed eye drops.
"CIPROFLOXACIN" (eye drops): instructions for use
Eye drops in the form of a three percent solution must be instilled into the conjunctival sac according to a scheme agreed upon with the attending physician. Without individualization according to the severity of the disease and the patient’s condition, the course of treatment is as follows:
- for acute bacterial conjunctivitis, simple blepharitis, scaly and ulcerative, as well as meibomitis, 1–2 drops are prescribed 4 to 8 times a day for 5–14 days;
- for keratitis, it is necessary to drip one drop six or more times a day for two to four weeks;
- for a bacterial corneal ulcer, the solution is instilled according to the following scheme: on the first day - drop by drop every 15 minutes for 6 hours, then: during the day - drop by drop every half hour; on the second day the interval is increased to an hour. And in subsequent periods - up to four hours;
- for acute dacryocystitis, 1 drop is prescribed 6 to 12 times a day for two weeks;
- for eye injuries - a drop 4–8 times a day for one to two weeks;
- during preoperative preparation, a drop every six hours for two days immediately before surgery.
After operations, one dose is given 4–6 times a day. The course can be short-term (5 days) or long-term (month).
Side effects that you should pay special attention to:
- an allergic reaction manifested in the form of burning, itching, hyperemia and pain;
- development of superinfection;
- nausea;
- change in taste;
- fear of light;
- swelling of the eyelids;
- lacrimation, decreased visual acuity;
- spots and infiltrates on the cornea.
An overdose of the drug in the form of a weak solution is excluded even if it is accidentally ingested, since the content of ciprofloxacin in one bottle is only 15 mg, which is 35 times lower than the maximum daily dose for children.
Indications
In ophthalmology, drops are prescribed for the following pathologies:
- Blepharitis.
- Conjunctivitis.
- A corneal ulcer that develops due to bacterial infection.
- Barley.
- Damage to the organs of vision as a result of penetration of solid foreign bodies or injuries accompanied by bacterial inflammation.
The medicinal solution in question is prescribed for infectious lesions of the ear, as well as in the event of a complication after eye surgery.
Analogues of "CIPROFLOXACIN" in tablets:
The described drug is the most affordable, so it is quite difficult to find analogues whose price is lower than the cost of Ciprofloxacin. However, if necessary, you can try replacing the drug with one of the following medications:
Normax . Norfloxacin-based drops intended for the treatment of infections caused by aerobic bacteria. The cost of this drug at the pharmacy is 150 rubles;
Norfloxacin is another drug based on the same active ingredient. The spectrum of action is similar to Ciprofloxacin. Price - 175 rubles;
Ciprolet is an analogue of Ciprofloxacin, a solution of the same active substance with an absolutely identical mechanism of action. Cost in pharmacies - 60 rubles;
Tsipromed . A local antibacterial drug, available in the form of a 3% solution for the eyes. Effective against most bacteria that cause inflammation in the eye. Price - 150 rubles.
pharmachologic effect
Ciprofloxacin eye drops have a broad range of action and are suitable for topical use in ophthalmology. The substance inhibits DNA gyrase, disrupts DNA production, growth and division of bacterial microorganisms. With the help of this tool, it is possible to achieve serious morphological changes and rapid death of bacterial cells.
The composition has a bactericidal effect on gram-negative microorganisms during division and dormancy. This is due to the fact that the drug affects not only DNA gyrase, but also provokes lysis of cell walls. At the same time, the substance affects gram-positive bacteria only during division.
Low toxicity for the cells of the macroorganism is associated with the absence of DNA gyrase in their structure. When using ciprofloxacin, there is no parallel synthesis of resistance to other antibiotics that do not belong to the category of gyrase inhibitors. This increases effectiveness against bacteria that are resistant to penicillins, tetracyclines, aminoglycosides and other substances. Getting used to the product develops quite slowly. After using an antibacterial substance, there are almost no persistent bacteria left. At the same time, microbial cells do not have enzymes that inactivate the agent.
"CIPROFLOXACIN": reviews
I was hospitalized after an eye injury. There was severe inflammation and swelling, and they wanted to operate. My attending physician decided to instill ciprofloxacin to relieve the effects of inflammation, just 3 days and the eye was already visible, the redness and swelling had gone away, the eye had completely opened. It turned out that a foreign body had gotten inside. After it was removed, the drops were continued for another 2 weeks - the eye was preserved, vision was normal.
I had conjunctivitis, and I actually had to soak my eyes every morning. Pain, tears, constant pain in the eyes, swelling. I consulted with a local ophthalmologist from the clinic, he advised me to take ciprofloxacin. I saw the price at the pharmacy and thought he was just kidding me. The price of my torment is 40 rubles! I bought it, used it for 5 days and then three more, as the instructions said. The conjunctivitis is completely gone!
